Cancer Research
The Mutational Fingerprint: Decoding Adenine's Outsized Role in Cancer Genomics
Across thousands of sequenced tumor genomes, a recurring pattern has emerged: adenine-rich sequences accumulate mutations at rates that cannot be explained by chance alone. Researchers are now interrogating why this single nucleotide appears so frequently at the epicenter of cancer-driving changes, and what those findings could mean for the next generation of screening tools and targeted oncology treatments. The answers are reshaping how scientists think about the origins of malignancy.